Natural gas and liquefied petroleum gas represent the most practical, realistic and easiest way to reduce pollution coming from road transportation. In practice, natural gas vehicles are as safe as any other vehicles (gasoline, diesel, liquefied petroleum gas, etc.) operating on the roads. However, safety incidents sometimes occur where a natural gas system, primarily storage cylinders, have failed. Recent incidents involving natural gas vehicles have shown that cylinders may explode through compliant with current UN ECE 110R regulation. In the paper are systematized regulations and technical requirements relating to the installation of devices and equipment on vehicles powered by natural gas. The main objective of the research is to present a good practice related to inspection of motor vehicles on natural gas. It was also shown the several options for the reconstruction of vehicles to drive on gas fuel, as well as logistics.